2018 Taiwan EXPO in Malaysia - Taiwan in Design2018 Taiwan Expo in Malaysia-Taiwan Healthcare Pavilion2018 Taiwan Expo in Malaysia-The Taiwan Smart-Care Seminar2018 Beijing International Cultural Industries Fair-Taiwan Cultural & Creative PavilionMIPCOM 2018Taiwan join the China International Licensing EXPO2018 Franchising & Licensing Asia (FLAsia)MIPCOM 2018MOU Signing Ceremony between TAITRA and IIEETaiwan - New South-Bound Franchise Industry Seminar & Matchmaking MeetingTaiwan join the TOKYO GAME SHOW,TGSTAITRA organized
The Taiwan IP trade delegation to expand New South market in Thailand and Singapore2018 Taiwan Healthcare Delegation to Mainland China (Dalian)2018 Taiwan Healthcare Delegation to Mainland China (Hangzhou)2018 Taiwan Talent Recruiting Mission to India2018 Guangzhou International Restaurant Franchise Exhibition2018 Shenzhen International IP Licensing & Cartoon Derivative Expo2018 Franchising Meeting2018 Taiwan Creative Industries Networking2018 Taiwan Health Care Delegation to PhilippinesIES Management College and Research Centre2018 Taiwan Health Industry Delegation to Vietnam2018 Taiwan Expo in Vietnam-Taiwan Healthcare Pavilion2018 MIRFNew Southbound Medical and Healthcare Exchange MOU Signing Ceremony2018 MEDICARE TAIWAN Promotes Specialty AllianceTAITRA Assists Taiwan’s designers and brands
to Explore Australian Cultural & Creative Opportunities2018 TAIWAN EXPO in India
Taiwan Healthcare PavilionGES 2018Cross-Strait Medical Specialty AllianceMOU Signing CeremonyFranchise Market Survey Conference2018 Business Opportunity
for China14 Taiwanese Gaming Companies
make Strong Gains at Game Connection America 2018TAITRA Witnesses the Establishment of 
“Taiwan Medical Specialty Alliance”TAITRA Promotes Taiwan Franchise Brands
to Expand into Western China MarketBubble Tea Industry International Marketing Practice Sharing Conference Taiwan Pavilion making a blast 
at the 2018 Hong Kong Licensing Show

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General
Zacatecas to conquer the European Market
The Mexican state of Zacatecas was participated in the International French Travel Market (IFTM), which was held from September 25th to 28th, in order to conquer the European Market through its culture, heritage and mining. This was the 1st time that the Mexican state participates in this fair, which brings together over 30,000 professionals from different parts of Europe. Gabriela Ibarra, the Deputy Minister of Tourism of Zacatecas, said that the French and Belgian markets have been explored since the beginning of 2018 when 8 operators were invited to learn about Zacatecas’s tourism and its products. “Not only Zacatecas, we know that travelers from other continents won`t visit just one state, we have to work together with other entities such as: Aguascalientes, San Luis Potosí, Guanajuato and Querétaro, to offer a tour of the region that complements the visits to beach destinations or to Mexico City,” said the official. Figures from the Tourism Promotion Council of Mexico (CPTM), 141,000 French citizens visit the country each year. In relation to 2017, this year the influx has increased by 7%.   Source:Notimex( http://www.notimex.gob.mx/)
Medical Service
Health City, project to boost Medical Tourism in Cancun, Mexico
The long-cherished medical tourism project for Cancún  began to crystallize during this month of October with a project called “Health City” on the grounds of Grupo Palace that have already begun development by third-party investors. Jabib Chapur, Vice-President of Food and Beverage of the Grupo Palace hotel chain, announced that the 1st hotel of the City Exprés chain inauguratedin October, while the 2nd lodging center of the NH Hotels firm is also in the final phase of construction. “It is a complex where the arrival of large firms of private hospitals and specialized services for retirees form the U.S.A., Canada and Europe is expected”, Jabib Chapur said. It is built in the territory reserve of the Palace chain, just 10 minutes away from the Cancun airport. In addition to medical services, a Dolphin Discovery dolphinarium is already in process, with an investment of US $3 million. The manager of the Palace chain said that the project will be developed almost entirely by third-party investors, but on land owned by Grupo Palace. Although there will be hotels and specialized lodging services, most of these establishments will be operated by other companies and not by Grupo Palace. Miguel Ángel Lemus, Vice-President of the Business Coordinating Council and real estate entrepreneur, said that it is a long-term project, since in addition to specialized clinics, the complex will feature shopping centers, convention centers, spas, housing areas, luxury condominiums, office buildings, entertainment areas, as well as spaces for scientific research. Since 2014, the construction of a similar project called Wisdoms Gardens was planned, promoted by the Medical Tourism Association of Quintana Roo, which involved the construction of six hospitals in the medium term: Pediatrics, Wellness & Antiaging, Orthopedic, Stem Cell Research Center, Oncology and Dental Clinic. In addition, it would have research and entertainment centers, shopping areas, restaurants, botanical gardens, meditation areas, art galleries, sports clubs, aquatic centers and artificial lakes.   Source:The Riviera Maya Times http://therivieramayatimes.com/  
Chinese Medicine
Cancer in China
INTRODUCTION ‘Lung cancer has the highest death rate among all types of cancers. In 2017 the most common cause of cancer death was still lung cancer in the United States, which contributes to more than a quarter of cancer mortality among all tumor types. In China, lung cancer is also the leading cause of cancer death for both males and females. Non-small cell lung cancer (NSCLC) accounts for 80%-85% of all lung cancers. Cisplatin-based chemotherapy has been widely used for patients with NSCLC in recent years. Although chemotherapy and targeted therapy have been improved in recent decades, the efficacy of chemotherapy for NSCLC is modest at present, and the 5-year survival rate of NSCLC is still unsatisfactory. Traditional Chinese Medicine (TCM) has been used in treatment of lung cancer for many years in China. The method of promoting Qi and activating blood is commonly used in the treatment. The combination of Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis) is one of the most common combinations in the method. The effective active ingredients of Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis), such as Astragalus saponins, Astragalus polysaccharide, β-elemene and Curcumin, have been reported to have anti-cancer effects. The research into the compatibility of Chinese herbs has risen from the herbal pieces level to the component formula level and the uniform experimental design has become a new valuable method in the compatibility research of Chinese medicine drugs. In this study, we used the uniform design method with a 4-factor and 8-level table to determine the optimal combination (E) of four components in Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis), namely Astragalus polysaccharide, Astragalus saponins, Curcumin and β-Elemene. Changes in the inhibition of A549 cell proliferation were observed as screening indices, and regression analysis was used to determine E. Using the chemical approach (CoCl2) to simulate hypoxia, we analyzed the expression of Bcl-2, Bax and caspase-3 in A549 lung cancer cells treated with various doses of E. MATERIALS AND METHODS Drugs and reagents Astragalus saponins and polysaccharide were purchased from Efebio Co., Ltd., (Shanghai, China). β-Elemene and Curcumin were purchased from the National Institutes for Food and Drug Control (Beijing, China). Antibody against Bax and antibody against β-actin were obtained from Abcam (Cambridge, UK). Antibody against caspase-3 was obtained from Cell Signaling Technology Inc. (Danvers, MA, USA). Antibody against Bcl-2, goat anti-rabbit IgG-horseradish peroxidase (HRP) and goat anti-mouse IgG-HRP were obtained from Santa Cruz Biotechnology Inc. (Santa Cruz, CA, USA). Trizol reagent was obtained from Invitrogen (Carlsbad, CA, USA). Other reagents included a HiFiMMLVcDNA First Strand Synthesis kit, Ultra-pure RNA extraction kit. An Annexin V-FITC/PI Apoptosis Detection kit and UltraSYBR mixture were obtained from CWbio Co., Ltd., (Beijing, China). A Cell Titer 96® AQueous One Solution Cell Proliferation Assay (MTS) was purchased from Promega (Madison, WI, USA). Cisplatin injection was obtained from Hospira (Mulgrave, Australia). CoCl2 was obtained from Sigma-Aldrich (St Louis, MO, USA). Cell culture and treatments The A549 human lung adenocarcinoma cell line was purchased from the Cell Center of the Chinese Academy of Medical Sciences (Beijing, China). The cells were cultured in Roswell Park Memorial Institute 1640 medium (RPMI-1640) (Gibco, NY, USA) containing 10% fetal bovine serum (Sijiqing, Hangzhou, China) and an antibioticmixture of Penicillin-Streptomycin Solution (Pasching, Austria). The cells were seeded on culture plates for each experiment and grown at 37 °C with 5% CO2. Astragalus saponins, Astragalus polysaccharide, Curcumin and β-Elemene were dissolved in dimethyl sulfoxide (DMSO) and diluted with RPMI-1640. The final concentration of DMSO never exceeded 5‰ (v/v). CoCl2 was dissolved in sterile water for injection and diluted with RPMI-1640. Cisplatin was diluted with RPMI-1640. In this study, the uniform design method was used to optimize the most effective component formula of Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis) in on effect of the proliferation of A549 lung cancer cells. A uniform design method with a 4-factor and 8-level table U8 (84) was used to optimize the proportions of four component in Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis), namely, Astragalus polysaccharide (X1), Astragalus saponins (X2), Curcumin (X3), and β-elemene (X4).Moreover, changes in the cellular proliferation inhibition rate (CPIR) were observed as evaluation indicator, and regression analysis was used to determine E.   RESULTS Proliferation inhibition of A549 cells A uniform design method with a 4-factor and 8-level table was used to optimize the proportions of four components in Huangqi (Radix Astragali Mongolici) and Ezhu (Rhizoma Curcumae Phaeocaulis) (Table 1). All CPIR observations of the eight uniform design groups were analyzed by stepwise regression analysis using SPSS 17.0 statistical software. Screening α into = α out = 0.15, two factors entered the model (X1 and X3), R2 = 0.805, it indicated that two influencing factors resulted in 80.5% CPIR variation and the model was relatively satisfactory. The optimal regression equation is = 0.003X1 + 0.26X3-0.503. Based on the partial regression coefficient, higher levels of X1 and X3 led to a higher CPIR. X2 and X4 were removed during the regression process, it indicated that changes of X2 and X4 did not affect the changes of CPIR. Therefore, the optimal test scheme obtained by the uniform design (E) was 200 mg/L Astragalus polysaccharide (X1) and 32 mg/L curcumin (X3). Apoptotic induction of A549 cells under chemical-induced hypoxia Apoptosis was analyses by flow cytometry in A549 cells. Results showed no significant difference between group 0 and group CoCl2 (P > 0.05). Compared with group 0, group DDP + CoCl2, 1E + CoCl2 and 2E + CoCl2 promoted the apoptosis rates of A549 cells (P < 0.05), and the apoptosis rates of group 0.5E + CoCl2, 1E + CoCl2 and 2E + CoCl2 were dose dependent. The apoptosis rates of the group 1E + CoCl2 and the group 2E + CoCl2 had no statistically significant difference compared with the group DDP + CoCl2 (P > 0.05).’   Source and URL : Science Direct 。https://www.sciencedirect.com
Logistics
Main Mexican airports report air cargo traffic increase
The January-August period of 2018 ended with a significant growth in cargo traffic for the main airports in Mexico, except for one, according to the Mexico´s Directorate General of Civil Aeronautics (DGAC for its acronym in Spanish). The San Luis Potosí airport is the only one, out of the eight main airports, to report a drop-in cargo handling. It accumulated 16,396 tons, a 6% decrease compared to 17,527 tons accumulated in the same period of 2017. The Mexico City International Airport registered 380,550 tons. This resulted in an increase of 10% compared to the 346,112 tons last year. Next on the list is the Guadalajara International Airport, which reported a total of 106,092 tons, 1% more than the 104,785 tons registered in 2017. Monterrey, on the other hand, had a 3% increase when contrasting this year´s 35,926 tons with the 34,774 tons of 2017. The Intercontinental Airport of Querétaro reported a 47% growth after 201,942 tons were reported, Toluca reached 23,786 tons, 20% more than the 19,840 tons of 2017. Cancun reported a cargo traffic of 21,115 tons, 11% more than the 19,037 tons last year. Lastly, Tijuana registered a 13%, as it accumulated 16,514, compared to 14,568 tons of last year. Source:Mexico Now https://mexico-now.com/index.php/article/4703-main-mexican-airports-report-air-cargo-traffic-increases  
General
Lime e-scooter rentals launches in Mexico City
United States micro-mobility company Lime has launched its electric scooter rental service in Mexico City. The battery-powered, shared scooters can be rented in the neighborhoods of Polanco, Anzures, Juárez, Condesa and Roma, all located to the west of Mexico City´s downtown. To access the service, Lime users pay around US $0.53 to unlock a scooter via a mobile app and then US $0.16 per minute. When a ride is completed, the dockless scooters can be parked by the curb of any street in the designated operating area. “Lime is committed to providing Mexico City with easy, quick and sustainable travel solutions,” said Alexander Wieland, Lime´s Mexico General Manager. Lime launched in June 2017 and has since entered more than 100 markets across the United States and Europe with its scooters and electric bikes. It is the 2nd scooter company to enter the Mexico City market after the Mexican company Grin, whose scooters are currently available in Roma and Condesa.   Source from “ Mexico News Daily” https://mexiconewsdaily.com/news/lime-scooter-rentals-launches-in-mexico-city/